Marc A. Pfeffer

Marc A. Pfeffer is the Dzau Professor of Medicine at Harvard Medical School and a senior physician in the Cardiovascular Division at Brigham and Women’s Hospital, Harvard University. He earned his MD and PhD from the University of Chicago and completed his residency and cardiology fellowship at the Peter Bent Brigham Hospital. Pfeffer’s research focuses on the treatment and management of heart failure, cardiovascular function and risk factors, and blood pressure and hypertension studies, with a particular emphasis on large-scale clinical trials and epidemiological investigations. His work has fundamentally advanced the understanding of post-myocardial infarction remodeling and heart failure therapies, notably through his leadership in landmark trials such as SAVE, CHARM, and PARADISE-MI. He has made major contributions to the study of cardio-kidney interactions, risk stratification in heart failure with preserved ejection fraction, and the totality of treatment effects in cardiovascular medicine. Pfeffer is an elected member of the National Academy of Medicine and has received numerous awards, including the American Heart Association’s Clinical Research Prize and the Heart Failure Society of America’s Lifetime Achievement Award. With an h-index of 169 and over 890 publications, his research continues to shape clinical guidelines and improve patient outcomes in cardiovascular care. Representative publications include "Right Ventricular Function and Pulmonary Coupling in Patients With Heart Failure and Preserved Ejection Fraction", and "Prognostic Importance of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) Following High-Risk Myocardial Infarction in the PARADISE-MI Trial", which reflect their ongoing engagement with the field.